The replisome is a protein complex that is required and sufficient for replication of both leading and lagging strands.
RecA colocalizes to the replisome in response to endogenous and exogenous DNA damage and in response to damage-independent fork arrest (formation of DNA repair centers), repair center formation depends on RecO and RecR, and is facilitated by RecF and SsbA PubMed
In vitro reconstitution of the replisome
Glenn M Sanders, H Garry Dallmann, Charles S McHenry
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases.
Mol. Cell: 2010, 37(2);273-81
Thomas R Beattie, Rodrigo Reyes-Lamothe
A Replisome's journey through the bacterial chromosome.
Front Microbiol: 2015, 6;562
Charles S McHenry
DNA replicases from a bacterial perspective.
Annu. Rev. Biochem.: 2011, 80;403-36
Patrick M Schaeffer, Madeleine J Headlam, Nicholas E Dixon
Protein--protein interactions in the eubacterial replisome.
IUBMB Life: 2005, 57(1);5-12
Other important publications
Masayuki Su'etsugu, Jeff Errington
The replicase sliding clamp dynamically accumulates behind progressing replication forks in Bacillus subtilis cells.
Mol. Cell: 2011, 41(6);720-32
Houra Merrikh, Cristina Machón, William H Grainger, Alan D Grossman, Panos Soultanas
Co-directional replication-transcription conflicts lead to replication restart.
Nature: 2011, 470(7335);554-7