PAS domain

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The PAS domain is a protein domain contained in many signaling proteins where it functions as a signal sensor. PAS domains are found in a large number of organisms from bacteria to humans. The PAS domain was named after the three proteins in which it was first discovered:

  • Per – period circadian protein
  • Arnt – aryl hydrocarbon receptor nuclear translocator protein
  • Sim – single-minded protein

B. subtilis proteins containing a PAS domain

Related SubtiWiki pages

Important reviews

Jonathan T Henry, Sean Crosson
Ligand-binding PAS domains in a genomic, cellular, and structural context.
Annu. Rev. Microbiol.: 2011, 65;261-86
[PubMed:21663441] [] [DOI] (I p)

Barry L Taylor
Aer on the inside looking out: paradigm for a PAS-HAMP role in sensing oxygen, redox and energy.
Mol. Microbiol.: 2007, 65(6);1415-24
[PubMed:17824925] [] [DOI] (P p)

Paul J A Erbel, Paul B Card, Ozgur Karakuzu, Richard K Bruick, Kevin H Gardner
Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Proc. Natl. Acad. Sci. U.S.A.: 2003, 100(26);15504-9
[PubMed:14668441] [] [DOI] (P p)

B L Taylor, I B Zhulin
PAS domains: internal sensors of oxygen, redox potential, and light.
Microbiol. Mol. Biol. Rev.: 1999, 63(2);479-506
[PubMed:10357859] [] (P p)

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