Nudix hydrolase

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Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.

Nudix hydrolases in Bacillus subtilis

Key reviews

A G McLennan
The Nudix hydrolase superfamily.
Cell. Mol. Life Sci.: 2006, 63(2);123-43
[PubMed:16378245] [WorldCat.org] [DOI] (P p)

A S Mildvan, Z Xia, H F Azurmendi, V Saraswat, P M Legler, M A Massiah, S B Gabelli, M A Bianchet, L-W Kang, L M Amzel
Structures and mechanisms of Nudix hydrolases.
Arch. Biochem. Biophys.: 2005, 433(1);129-43
[PubMed:15581572] [WorldCat.org] [DOI] (P p)

M J Bessman, D N Frick, S F O'Handley
The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes.
J. Biol. Chem.: 1996, 271(41);25059-62
[PubMed:8810257] [WorldCat.org] (P p)