NadD

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  • Description: nicotinamide-nucleotide adenylyltransferase

Gene name nadD
Synonyms yqeJ
Essential yes PubMed
Product nicotinamide-nucleotide adenylyltransferase
Function NAD biosynthesis
Gene expression levels in SubtiExpress: nadD
Metabolic function and regulation of this protein in SubtiPathways:
NadD
MW, pI 22 kDa, 5.123
Gene length, protein length 567 bp, 189 aa
Immediate neighbours yqeK, yqeI
Sequences Protein DNA DNA_with_flanks
Genetic context
YqeJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NadD expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU25640

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ (according to Swiss-Prot)
  • Protein family: nadD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Andrea M Olland, Kathryn W Underwood, Robert M Czerwinski, Mei-Chu Lo, Ann Aulabaugh, Joel Bard, Mark L Stahl, William S Somers, Francis X Sullivan, Rajiv Chopra
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J. Biol. Chem.: 2002, 277(5);3698-707
[PubMed:11704676] [WorldCat.org] [DOI] (P p)