msmX

msmX
168

multiple sugar [wiki|ABC transporter ](ATP-binding protein)

locus
BSU_38810
Molecular weight
41.21 kDa
pI
7.39
Protein length
Gene length
function
uptake of maltodextrin, melibiose (probably), and galactooligosaccharides
product
multiple sugar [wiki|ABC transporter ](ATP-binding protein)
essential
no
synonyms
msmX, yxkG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3839 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,984,133  3,985,230
Phenotypes of a mutant
no growth with pectin or galactan as single carbon source [pubmed|29240795]
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The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 4-235) (according to UniProt)
Structure
[PDB|1G29] (from Thermococcus litoralis, 54% identity) [pubmed|11080142]
[AF|P94360]
Paralogous protein(s)
[protein|3B9331D6755B8253944AB33521BBF2B3EBA4CAEB|frlP], [protein|3F502A4DCB1DAD7C3F968465B13C35213240515B|opuBA]
[wiki|Localization]
septal at the cell membrane [Pubmed|20566861]
septal localization partially depends on the proton motive force [Pubmed|20566861]
[protein|559DEDC9887B811EF80994526256ADC48BA51CE3|noc] and the Min system ensure the efficient utilization of the division site at midcell in by ensuring [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|Z ring]]] placement [Pubmed|22457634]
[protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] is anchored to the cell membrane by either [protein|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA] or [protein|DB09F1C36257F511A84A083967A25A9D46744D14|sepF] [Pubmed|24218584,16159787]"],"Additional information":["the novel antibiotic ADEP (acyldepsipeptides) causes [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] degradation via dysregulation [protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP] activity (activity occurs even in the absence of an ATPase subunit ([protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC], [protein|8C5B14FE5E03427F9A598C75D4081FA0D6696299|clpE], or [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX])) [Pubmed|21969594]
[protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] is unfolded for N-terminal degradation by antibiotic-activated [protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP] [pubmed|32605984]
Expression and Regulation
Operons
genes
[gene|9EE268C3DC3C0F2F846DAEB2004222B6F841B9EA|yxkF]-[gene|434F6C546F783503A82D390FD238F05025FC1802|msmX]
description
[Pubmed|10746760]
regulation
repressed by glucose ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]) [Pubmed|10666464]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
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[gene|9EE268C3DC3C0F2F846DAEB2004222B6F841B9EA|yxkF]→[gene|434F6C546F783503A82D390FD238F05025FC1802|msmX]

2024-03-29 06:13:02

Jstuelk

47

AF2FCB62C3853F05544C97E9ABCDF316421AD12D

84C66B43C7822D0A3BB4809B557110959136271B

Biological materials
Mutant
MGNA-B741 (msmX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1740 NBRP B. subtilis, Japan]
BKE38810 ([gene|434F6C546F783503A82D390FD238F05025FC1802|msmX]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38810 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTAACATCCCCCTTTGT,  downstream forward: _UP4_TAAGATCAAAAAAACCGGAC
BKK38810 ([gene|434F6C546F783503A82D390FD238F05025FC1802|msmX]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38810 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTAACATCCCCCTTTGT,  downstream forward: _UP4_TAAGATCAAAAAAACCGGAC
References
10092453,16672620,10746760,16707683,10666464,22900538,27501980,29240795,11080142,31138628,33177617,35171018

434F6C546F783503A82D390FD238F05025FC1802

Page visits: 4471

Time of last update: 2024-03-28 20:03:27

Author of last update: Jstuelk