MhqR

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Gene name mhqR
Synonyms ykvE
Essential no
Product MarR-family transcriptional repressor
Function regulation of resistance to quinones and diamide
Gene expression levels in SubtiExpress: mhqR
MW, pI 16 kDa, 6.42
Gene length, protein length 435 bp, 145 aa
Immediate neighbours kinD, motB
Sequences Protein DNA DNA_with_flanks
Genetic context
YkvE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MhqR expression.png

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Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The MhqR regulon

The gene

Basic information

  • Locus tag: BSU13670

Phenotypes of a mutant

  • resistant to quinones and diamide

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

  • Binding site: tATCTcgaAtTCgAGATaaaa PubMed

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Your additional remarks

References

Reviews

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)


Original articles

Stefanie Töwe, Montira Leelakriangsak, Kazuo Kobayashi, Nguyen Van Duy, Michael Hecker, Peter Zuber, Haike Antelmann
The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol. Microbiol.: 2007, 66(1);40-54
[PubMed:17725564] [WorldCat.org] [DOI] (P p)

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