LysM domain

From SubtiWiki
Jump to: navigation, search

LysM domains have affinity for N-acetylglucosamine polymers (GlcNac) in the lower μM range. A single LysM domain is able to bind carbohydrate ligands and LysM domains act additively to increase the binding-affinity.

B. subtilis proteins containing a LysM domain

---

Related SubtiWiki pages

Important reviews

Girbe Buist, Anton Steen, Jan Kok, Oscar P Kuipers
LysM, a widely distributed protein motif for binding to (peptido)glycans.
Mol. Microbiol.: 2008, 68(4);838-47
[PubMed:18430080] [WorldCat.org] [DOI] (I p)

Important original publications

Jaslyn E M M Wong, Husam M A B Alsarraf, Jørn Døvling Kaspersen, Jan Skov Pedersen, Jens Stougaard, Søren Thirup, Mickaël Blaise
Cooperative binding of LysM domains determines the carbohydrate affinity of a bacterial endopeptidase protein.
FEBS J.: 2014, 281(4);1196-208
[PubMed:24355088] [WorldCat.org] [DOI] (I p)


Back to Domains