L-box

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The L-box is a riboswitch that binds lysine and controls gene expression by a termination/ antitermination mechanism. Upon binding of lysine, the L-box adopts a terminator structure thtus preventing expression of lysC. In the absence of lysine, the L-box has an antiterminator structure that allows lysC expression and thus lysine biosynthesis.

Contents

Gene controlled by a L-box mechanism

References

Larry R Fiegland, Andrew D Garst, Robert T Batey, David J Nesbitt
Single-molecule studies of the lysine riboswitch reveal effector-dependent conformational dynamics of the aptamer domain.
Biochemistry: 2012, 51(45);9223-33
[PubMed:23067368] [WorldCat.org] [DOI] (I p)

Sharnise N Wilson-Mitchell, Frank J Grundy, Tina M Henkin
Analysis of lysine recognition and specificity of the Bacillus subtilis L box riboswitch.
Nucleic Acids Res.: 2012, 40(12);5706-17
[PubMed:22416067] [WorldCat.org] [DOI] (I p)

Simon Blouin, Raja Chinnappan, Daniel A Lafontaine
Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation.
Nucleic Acids Res.: 2011, 39(8);3373-87
[PubMed:21169337] [WorldCat.org] [DOI] (I p)

Kenneth F Blount, Joy Xin Wang, Jinsoo Lim, Narasimhan Sudarsan, Ronald R Breaker
Antibacterial lysine analogs that target lysine riboswitches.
Nat. Chem. Biol.: 2007, 3(1);44-9
[PubMed:17143270] [WorldCat.org] [DOI] (P p)

Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
Nucleic Acids Res.: 2003, 31(23);6748-57
[PubMed:14627808] [WorldCat.org] (I p)

Narasimhan Sudarsan, J Kenneth Wickiser, Shingo Nakamura, Margaret S Ebert, Ronald R Breaker
An mRNA structure in bacteria that controls gene expression by binding lysine.
Genes Dev.: 2003, 17(21);2688-97
[PubMed:14597663] [WorldCat.org] [DOI] (P p)

Frank J Grundy, Susan C Lehman, Tina M Henkin
The L box regulon: lysine sensing by leader RNAs of bacterial lysine biosynthesis genes.
Proc. Natl. Acad. Sci. U.S.A.: 2003, 100(21);12057-62
[PubMed:14523230] [WorldCat.org] [DOI] (P p)


See also:

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