ispD

ispD
168

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, third step in the MEP pathway of isoprenoid biosynthesis

locus
BSU_00900
Molecular weight
25.70 kDa
pI
5.58
Protein length
Gene length
function
MEP pathway of isoprenoid biosynthesis
product
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
essential
yes
ec
2.7.7.60
synonyms
ispD, yacM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1211 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
109,789 → 110,487
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
2-C-methyl-D-erythritol 4-phosphate + CTP + H+ --> 4-CDP-2-C-methyl-D-erythritol + diphosphate (according to UniProt)
Protein family
cytidylyltransferase family (with [protein|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD] and [protein|B25AE6979AF12628780C4489FFED966C6B31968A|yfnH], according to UniProt)
IspD/TarI cytidylyltransferase family (single member, according to UniProt)
Structure
[PDB|5DDT] [Pubmed|27821871]
[PDB|5DDV] [Pubmed|27821871]
[AF|Q06755]
Expression and Regulation
Operons
genes
[gene|179FDEA51A060DF32A3EA06A796793DE27B600FF|yacL]-[gene|CF9633F769263C6D16EE778F6BD2ECF1995F512A|ispD]-[gene|1A6793A3A5AC568C67873C8708E9F581F42AB9BA|ispF]
description
[Pubmed|10482513]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|17434969], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
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[gene|179FDEA51A060DF32A3EA06A796793DE27B600FF|yacL]→[gene|1A6793A3A5AC568C67873C8708E9F581F42AB9BA|ispF]

2024-01-17 22:43:38

ghost

51

7dc686870ed58f71ca9e5b0841c69a922f74d84a

EFDC5F8C8F63B342C29A9AB39CD8005147D16917

Biological materials
Mutant
MGNA-B881 (yacM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1880 NBRP B. subtilis, Japan]
References
15805528,10482513,17458547,17434969,23840410,21766403,27821871,29335298

CF9633F769263C6D16EE778F6BD2ECF1995F512A

Page visits: 4533

Time of last update: 2024-03-29 00:09:33

Author of last update: Melvin.boenninger