hxlA

hxlA
168

3-hexulose-6-phosphate synthase

locus
BSU_03460
Molecular weight
22.43 kDa
pI
4.56
Protein length
Gene length
function
ribulose monophosphate pathway for formaldehyde fixation
product
3-hexulose-6-phosphate synthase
essential
no
ec
4.1.2.43
synonyms
hxlA, yckG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0269 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
375,166 → 375,798
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The protein
Catalyzed reaction/ biological activity
D-ribulose 5-phosphate + formaldehyde --> D-arabino-hex-3-ulose 6-phosphate (according to UniProt)
Protein family
HPS/KGPDC family (single member, according to UniProt)
Structure
[PDB|3F4W] (from Salmonella typhimurium, 44% identity)
[AF|P42405]
Expression and Regulation
Operons
genes
[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]-[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]
description
[Pubmed|10572115]
regulation
induction by formaldehyde ([protein|search|HxlR]) [Pubmed|10572115]
regulatory mechanism
[protein|D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR]: activation, [Pubmed|10572115], in [regulon|protein:D9A187961CFB9496A6712E9E48AAD384357A3E1C|hxlR regulon]
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[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]→[gene|FB0CEA291CA4EC5FB8410050E61B89EDBA1771F9|hxlB]

2024-03-29 06:09:11

ghost

35

6c10d03b49996cafc4e7998221aed8543c838ba7

F9646F9344120B58E62D49A95B651C27C88E36F6

Biological materials
Mutant
MGNA-C057 (yckG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2055 NBRP B. subtilis, Japan]
BKE03460 (Δ[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03460 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTGATCCACTCCCTT,  downstream forward: _UP4_CTGATTGTCCAAGGATAACT
BKK03460 (Δ[gene|BF480721B89661BFFE6632BB10C5F4DC29951784|hxlA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03460 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTGATCCACTCCCTT,  downstream forward: _UP4_CTGATTGTCCAAGGATAACT
References
10572115,16428816,19170879

BF480721B89661BFFE6632BB10C5F4DC29951784

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Time of last update: 2024-03-28 10:35:47

Author of last update: Melvin.boenninger