Transcription factors of the GntR family

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A large family of transcription factors. DNA-binding occurs via a winged helix-turn-helix motif and is mostly controlled by low molecular weight effectors. The family has four subfamilies, that differ in their effector-binding domains.

Members of the HutC subfamily in B. subtilis

Members of the YtrA subfamily in B. subtilis

Members of the FadR subfamily in B. subtilis

Additional GntR family regulator

Transcription factors with a DNA-binding domain of the GntR family, but different effector-binding domain


Inna A Suvorova, Yuri D Korostelev, Mikhail S Gelfand
GntR Family of Bacterial Transcription Factors and Their DNA Binding Motifs: Structure, Positioning and Co-Evolution.
PLoS One: 2015, 10(7);e0132618
[PubMed:26151451] [] [DOI] (I e)

Paul A Hoskisson, Sébastien Rigali
Chapter 1: Variation in form and function the helix-turn-helix regulators of the GntR superfamily.
Adv Appl Microbiol: 2009, 69;1-22
[PubMed:19729089] [] [DOI] (P p)

Sébastien Rigali, Adeline Derouaux, Fabrizio Giannotta, Jean Dusart
Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies.
J Biol Chem: 2002, 277(15);12507-15
[PubMed:11756427] [] [DOI] (P p)

D J Haydon, J R Guest
A new family of bacterial regulatory proteins.
FEMS Microbiol Lett: 1991, 63(2-3);291-5
[PubMed:2060763] [] [DOI] (P p)

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