folB

folB
168

dihydroneopterin aldolase

locus
BSU_00780
Molecular weight
13.38 kDa
pI
5.23
Protein length
Gene length
function
biosynthesis of folate
product
dihydroneopterin aldolase
essential
yes
ec
4.1.2.25
synonyms
folB, folA, yacE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1539 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
86,587  86,949
Phenotypes of a mutant
essential [Pubmed|28189581]
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The protein
Catalyzed reaction/ biological activity
7,8-dihydroneopterin --> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde (according to UniProt)
Protein family
DHNA family (single member, according to UniProt)
Structure
[PDB|1U68] (from ''Staphylococcus aureus'', 47% identity, 72% similarity) [Pubmed|15027862]
[AF|P28823]
Expression and Regulation
Operons
genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|yacF]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]→[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]

2024-03-14 03:48:43

Jstuelk

73

8c465dd3eec1aaa32d5e91206834f9bb99ef474a

7B9041CE94396BF42D285F7C0EDD3A2544761EEE

References
9084182,28189581, 11918677

AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787

Page visits: 2238

Time of last update: 2024-03-28 10:17:06

Author of last update: Melvin.boenninger