ffh

ffh
168

signal recognition particle (SRP) component

locus
BSU_15980
Molecular weight
49.38 kDa
pI
9.42
Protein length
Gene length
function
presecretory protein translocation
product
signal recognition particle (SRP) component
essential
yes
synonyms
ffh

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0541 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,672,174 → 1,673,514
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Protein family
GTP-binding SRP family (with [protein|BB6F5D7463EF96E2C6344D0BC30A227C5E3B5817|flhF] and [protein|D519765BF5261E48512CE86245BD7B733F188D4A|ftsY], according to UniProt)
Structure
[PDB|4UE4] (complex [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh]-[protein|097C817A5A3E31F73F6ABC4AA95852A64E43A057|scr] RNA) [Pubmed|26344568]
[AF|P37105]
Effectors of protein activity
(p)ppGpp binds to [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh] thus preventing membrane targeting of proteins [pubmed|35217658]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|8F559BFC80FE56EA0389A2336F4E9E6908562BCB|ylxM]-[gene|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh]-[gene|25C4850812DC216C1BEFBF07DCA71CC6820930B0|rpsP]-[gene|67FB5F6FB0B2701BD8E4FDD8DF06B236DE6A2599|khpA]
description
[pubmed|36840557]
regulation
the mRNA is processed between [gene|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh] and [gene|25C4850812DC216C1BEFBF07DCA71CC6820930B0|rpsP] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
expression
expression is decreased upon depletion of tRNA maturation factors [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] or [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz] [pubmed|36840557]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8335643], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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Array

2024-03-21 22:21:17

Jstuelk

26

0C22E9A74563E6DB840352CF68BC5D70BBD11EAB

0C22E9A74563E6DB840352CF68BC5D70BBD11EAB

genes
[gene|8F559BFC80FE56EA0389A2336F4E9E6908562BCB|ylxM]-[gene|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh]-[gene|25C4850812DC216C1BEFBF07DCA71CC6820930B0|rpsP]-[gene|67FB5F6FB0B2701BD8E4FDD8DF06B236DE6A2599|khpA]-[gene|0AB1FB44E8F28944B82B5EF14A9CDCFEE46DB76B|ylqD]-[gene|34B0FA6E7E25D1E5D8A54B70F5562BD0BD05B498|rimM]-[gene|885ECD9FAAC8BC95D32F049825D6B6244C046112|trmD]-[gene|51368512B8322EDBCA92674EC2B97CF26087D8A9|rplS]
description
[Pubmed|29794222]
regulation
the mRNA is processed between [gene|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|ffh] and [gene|25C4850812DC216C1BEFBF07DCA71CC6820930B0|rpsP] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
expression
expression is decreased upon depletion of tRNA maturation factors [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] or [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz] [pubmed|36840557]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8335643], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|8F559BFC80FE56EA0389A2336F4E9E6908562BCB|ylxM]→[gene|51368512B8322EDBCA92674EC2B97CF26087D8A9|rplS]

2024-02-07 15:26:05

Jstuelk

82

4F2FF9A3B937EE85312D0B0F9DA494E4B44E2297

417C7007C2492335257F8AEF606BB8627753757F

References
Reviews
25212246,27890920
Original Publications
16705751,9346318,9880811,8335643,21330537,23563142,24659773,26344568,29794222,35217658,36815589,36840557

EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208

Page visits: 4963

Time of last update: 2024-03-26 18:18:52

Author of last update: Jstuelk