dnaB

dnaB
168

initiation of chromosome replication/ membrane attachment protein, part of the [wiki|replisome]

locus
BSU_28990
Molecular weight
54.72 kDa
pI
5.28
Protein length
Gene length
function
[category|SW.3.1.1|DNA replication]
product
helicase loader, initiation of chromosome replication/ membrane attachment protein
essential
yes
synonyms
dnaB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3611 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,964,148  2,965,566
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
binds double-stranded DNA and co-loads the replicative helicase [pubmed|32817095]
Structure
[PDB|5WTN] (from Geobacillus stearothermophilus, 47% identity, N-terminal domain, aa 1 - 300) [pubmed|28808061]
[AF|P07908]
[wiki|Localization]
Membrane-proximal (Spotty) [Pubmed|16479537]
forms foci, close to oriC [Pubmed|10844689]
Expression and Regulation
Operons
genes
[gene|2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7|dnaB]-[gene|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[gene|72A4458679EA1451FA3B63D44C3BE93ACA8B397F|ytxB]-[gene|3EE0D03469D893515CAA4961BF923BE3A6769535|ytxC]-[gene|3E1131CFA3EDEB3865638F09BE2F6B6ED2570BE2|thrS]
description
[Pubmed|22383849]
Open in new tab

[gene|2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7|dnaB]→[gene|3E1131CFA3EDEB3865638F09BE2F6B6ED2570BE2|thrS]

2024-03-10 08:56:27

Jstuelk

81

86944789c9fccd66104bd44b9e445a3dc0b7ffc0

B3B673302E6466DA20A850B2B832501BE5C0DACF

References
Reviews
22797751,28075389,36877032
Original Publications
19707554,28808061,15686560,12718886,2554322,11250911,15186423,11842108,11585815,16479537,19415803,14757052,10844689,12974630,19968790,20071750,11679082,20122408,20199598,20587500,21097613,30285297,32817095,35576203,36416272

2AEF6D56D884CA6A0BD50FABD27F405DC2B506C7

Page visits: 5770

Time of last update: 2024-03-28 08:11:20

Author of last update: Jstuelk