cydA

cydA
168

cytochrome bd ubiquinol oxidase (subunit I), high affinity terminal oxidase

locus
BSU_38760
Molecular weight
52.13 kDa
pI
8.94
Protein length
Gene length
function
respiration
product
cytochrome bd ubiquinol oxidase (subunit I), high affinity terminal oxidase
essential
no
synonyms
cydA, yxkK

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1271 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,977,791 → 3,979,197
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The protein
Catalyzed reaction/ biological activity
2 ubiquinol + n H+ + O2 --> 2 ubiquinone + n H+ + 2 H2O (according to UniProt)
Protein family
cytochrome ubiquinol oxidase subunit 1 family (with [protein|EB8AF295A11F28BDFAE39038FA89890824FC7791|ythA], according to UniProt)
[wiki|Cofactors]
heme b, heme d (according to UniProt)
Structure
[PDB|5DOQ] (from Geobacillus thermodenitrificans, 30% identity) [pubmed|27126043]
[AF|P94364]
Paralogous protein(s)
[protein|EB8AF295A11F28BDFAE39038FA89890824FC7791|ythA]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]-[gene|A65576E0261F1950A0DAD72B2432D97AB3EB2AA5|cydC]-[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[Pubmed|16207915]
regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|17322317]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|rex]: repression, [Pubmed|15231791], in [regulon|protein:B5EF521437323EF43F08E5EFDB5C798616CA499A|rex regulon]
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|17322317], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [PubMed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
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[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]→[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]

2024-03-15 09:21:47

Jstuelk

66

B656DC522BB35F8FB6BB0C0BBC86CB05C20AB7C7

80895031322ED50D8EABA337924455145A6261DF

Biological materials
Mutant
MGNA-B745 (cydA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1744 NBRP B. subtilis, Japan]
BKE38760 (Δ[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTCTCCTCCATTTC,  downstream forward: _UP4_GATCCATTTAGTCAGGAGGT
BKK38760 (Δ[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCTTTCTCCTCCATTTC,  downstream forward: _UP4_GATCCATTTAGTCAGGAGGT
lacZ fusion
pGP3879 (kan, based on [wiki|pAC7]]), available in [wiki|Jörg Stülke]'s lab
GP4302 ([gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-lacZ::aphA3), available in [wiki|Jörg Stülke]'s lab
References
Reviews
33705278
Original Publications
16207915,17322317,17015645,15231791,9852001,10551842,15231791,17322317,27126043,36422766

C0459C0D45E31561D281E016D86CD80DCAF13357

Page visits: 3458

Time of last update: 2024-03-27 13:13:22

Author of last update: Dennis.wicke