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Condensin is a conserved protein complex that binds the origin region of the DNA. It is required for segregation of the origin regions after DNA replication. Condensin is a central modulator of chromosome superstructure in all domains of life.

Mutants lacking condensin components are viable as long as they grow slowly (i.e. on minimal medium), but the components are essential for rapid growth (on LB).

Localization of the condensin complex depends on ParB. The condensin (Smc)2-ScpA-ScpB complex is loaded by [SW|ParB] to parS centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]

The condensin complex: Smc2-ScpA-ScpB

Back to protein-protein interactions

Important publications

Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny
Chromosome organization by one-sided and two-sided loop extrusion.
Elife: 2020, 9;
[PubMed:32250245] [] [DOI] (I e)

Hugo B Brandão, Payel Paul, Aafke A van den Berg, David Z Rudner, Xindan Wang, Leonid A Mirny
RNA polymerases as moving barriers to condensin loop extrusion.
Proc Natl Acad Sci U S A: 2019, 116(41);20489-20499
[PubMed:31548377] [] [DOI] (I p)

Roberto Vazquez Nunez, Laura B Ruiz Avila, Stephan Gruber
Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin.
Mol Cell: 2019, 75(2);209-223.e6
[PubMed:31201090] [] [DOI] (I p)

John F Marko, Paolo De Los Rios, Alessandro Barducci, Stephan Gruber
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes.
Nucleic Acids Res: 2019, 47(13);6956-6972
[PubMed:31175837] [] [DOI] (I p)

Xindan Wang, Hugo B Brandão, Tung B K Le, Michael T Laub, David Z Rudner
Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.
Science: 2017, 355(6324);524-527
[PubMed:28154080] [] [DOI] (I p)

HyeongJun Kim, Joseph J Loparo
Multistep assembly of DNA condensation clusters by SMC.
Nat Commun: 2016, 7;10200
[PubMed:26725510] [] [DOI] (I e)

Isabella V Hajduk, Christopher D A Rodrigues, Elizabeth J Harry
Connecting the dots of the bacterial cell cycle: Coordinating chromosome replication and segregation with cell division.
Semin Cell Dev Biol: 2016, 53;2-9
[PubMed:26706151] [] [DOI] (I p)

Martial Marbouty, Antoine Le Gall, Diego I Cattoni, Axel Cournac, Alan Koh, Jean-Bernard Fiche, Julien Mozziconacci, Heath Murray, Romain Koszul, Marcelo Nollmann
Condensin- and Replication-Mediated Bacterial Chromosome Folding and Origin Condensation Revealed by Hi-C and Super-resolution Imaging.
Mol Cell: 2015, 59(4);588-602
[PubMed:26295962] [] [DOI] (I p)

Xindan Wang, Tung B K Le, Bryan R Lajoie, Job Dekker, Michael T Laub, David Z Rudner
Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis.
Genes Dev: 2015, 29(15);1661-75
[PubMed:26253537] [] [DOI] (I p)

Larissa Wilhelm, Frank Bürmann, Anita Minnen, Ho-Chul Shin, Christopher P Toseland, Byung-Ha Oh, Stephan Gruber
SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis.
Elife: 2015, 4;
[PubMed:25951515] [] [DOI] (I e)

Young-Min Soh, Frank Bürmann, Ho-Chul Shin, Takashi Oda, Kyeong Sik Jin, Christopher P Toseland, Cheolhee Kim, Hansol Lee, Soo Jin Kim, Min-Seok Kong, Marie-Laure Durand-Diebold, Yeon-Gil Kim, Ho Min Kim, Nam Ki Lee, Mamoru Sato, Byung-Ha Oh, Stephan Gruber
Molecular basis for SMC rod formation and its dissolution upon DNA binding.
Mol Cell: 2015, 57(2);290-303
[PubMed:25557547] [] [DOI] (I p)

Xindan Wang, Paula Montero Llopis, David Z Rudner
Bacillus subtilis chromosome organization oscillates between two distinct patterns.
Proc Natl Acad Sci U S A: 2014, 111(35);12877-82
[PubMed:25071173] [] [DOI] (I p)

Thomas G W Graham, Xindan Wang, Dan Song, Candice M Etson, Antoine M van Oijen, David Z Rudner, Joseph J Loparo
ParB spreading requires DNA bridging.
Genes Dev: 2014, 28(11);1228-38
[PubMed:24829297] [] [DOI] (I p)

Stephan Gruber, Jan-Willem Veening, Juri Bach, Martin Blettinger, Marc Bramkamp, Jeff Errington
Interlinked sister chromosomes arise in the absence of condensin during fast replication in B. subtilis.
Curr Biol: 2014, 24(3);293-8
[PubMed:24440399] [] [DOI] (I p)

Xindan Wang, Olive W Tang, Eammon P Riley, David Z Rudner
The SMC condensin complex is required for origin segregation in Bacillus subtilis.
Curr Biol: 2014, 24(3);287-92
[PubMed:24440393] [] [DOI] (I p)

Sophie Nolivos, David Sherratt
The bacterial chromosome: architecture and action of bacterial SMC and SMC-like complexes.
FEMS Microbiol Rev: 2014, 38(3);380-92
[PubMed:24118085] [] [DOI] (I p)

Rahul Thadani, Frank Uhlmann, Sebastian Heeger
Condensin, chromatin crossbarring and chromosome condensation.
Curr Biol: 2012, 22(23);R1012-21
[PubMed:23218009] [] [DOI] (I p)

Tatsuya Hirano
Condensins: universal organizers of chromosomes with diverse functions.
Genes Dev: 2012, 26(15);1659-78
[PubMed:22855829] [] [DOI] (I p)