ComN

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  • Description: mediates post-transcriptional control of comE operon expression

Gene name comN
Synonyms yrzD
Essential no
Product post-transcriptional regulator of comE expression
Function regulation of competence and DNA uptake
Gene expression levels in SubtiExpress: comN
Interactions involving this protein in SubtInteract: ComN
MW, pI 11 kDa, 4.622
Gene length, protein length 294 bp, 98 aa
Immediate neighbours secDF, spoVB
Sequences Protein DNA DNA_with_flanks
Genetic context
YrzD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComN expression.png

Contents















Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

The ComN regulon: comEA-comEB-comEC

The gene

Basic information

  • Locus tag: BSU27660

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • post-transcriptional control of comEA expression PubMed
    • promotes the accumulation of its target comEA mRNA to septal and polar sites PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 140 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Valquiria Tiago dos Santos, Alexandre W Bisson-Filho, Frederico J Gueiros-Filho
DivIVA-mediated polar localization of ComN, a posttranscriptional regulator of Bacillus subtilis.
J. Bacteriol.: 2012, 194(14);3661-9
[PubMed:22582279] [WorldCat.org] [DOI] (I p)

Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J. Bacteriol.: 2009, 191(3);949-58
[PubMed:19028902] [WorldCat.org] [DOI] (I p)

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