argH

argH
168

argininosuccinate lyase

locus
BSU_29440
Molecular weight
51.76 kDa
pI
4.86
Protein length
Gene length
function
biosynthesis of arginine
product
argininosuccinate lyase
essential
no
ec
4.3.2.1
synonyms
argH

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0165 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,011,751  3,013,136
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
2-(Nω-L-arginino)succinate --> fumarate + L-arginine (according to UniProt)
Protein family
[wiki|lyase 1 family] (according to UniProt)
Structure
[PDB|1TJ7] (from ''Escherichia coli'', 47% identity, 64% similarity) [Pubmed|15502303]
[AF|O34858]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|94E5DA4F460FBC02A186D1013C581179F13BCB3E|argG]-[gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH]
description
[Pubmed|22383849]
regulation
repressed by arginine ([protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC])
induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM] [pubmed|30355672]
regulatory mechanism
[protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC]: repression, in [regulon|protein:62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC regulon]
[protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM]: unknown, [pubmed|30355672], in [regulon|protein:F4097349A563503468A2A14F062AEAC532C7917A|rnpM regulon]
Open in new tab

[gene|94E5DA4F460FBC02A186D1013C581179F13BCB3E|argG]→[gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH]

2024-02-07 04:16:36

Jstuelk

53

1c207e814f33fb3d04dcc49c4c9da5b8d9da0a69

F891D79BBED99BE9F3E6174F94CE2EF8EDC02509

Biological materials
Mutant
GP1688 Δ([gene|94E5DA4F460FBC02A186D1013C581179F13BCB3E|argG]-[gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH])::''aphA3'', available in [wiki|Jörg Stülke]'s lab
GP3712 ([gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH]::aphA3 trpC2) available in the [wiki|Stülke] lab
BKE29440 ([gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29440 BGSC] and in [wiki|Jörg Stülke]'s lab GP3925,  [Pubmed|28189581], upstream reverse: _UP1_AAATCGGCCTCCCCAAAGCT,  downstream forward: _UP4_TAAAATTTCCTTCATAAAAT
BKK29440 ([gene|571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312|argH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AAATCGGCCTCCCCAAAGCT,  downstream forward: _UP4_TAAAATTTCCTTCATAAAAT
Expression vectors
pGP3764: expression of Strep-''argH'' by [wiki|pGP380] in ''B. subtilis'' suitable for [wiki|SPINE], available in [wiki|Jörg Stülke]'s lab
pGP3779: IPTG inducible expression, purification in ''E. coli'' with N-terminal Strep-tag, in [wiki|pGP172], available in [wiki|Jörg Stülke]'s lab
References
12107147,21821766,22383849

571789ADA1F7B9DE0F9E205E2DEB9C9166F6C312

Page visits: 2107

Time of last update: 2024-03-27 02:03:27

Author of last update: Robert.warneke