araL

araL
168

sugar phosphate phosphatase, L-arabinose operon

locus
BSU_28770
Molecular weight
29.16 kDa
pI
5.37
Protein length
Gene length
function
detoxification of accidental accumulation of phosphorylated metabolites
product
sugar phosphate phosphatase
essential
no
synonyms
araL, yseA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0647 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,944,187 → 2,945,005
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The protein
Catalyzed reaction/ biological activity
H2O + O-phospho-L-serine --> L-serine + phosphate (according to UniProt)
H2O + O-phospho-D-serine --> D-serine + phosphate (according to UniProt)
Protein family
[wiki|HAD superfamily] (according to UniProt)
Structure
[PDB|3QGM] (from ''Archaeoglobus Fulgidus'' (35%) )
[AF|P94526]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|028428CE456E283C065756878EA7C7DB495DD10D|araA]-[gene|E0525A4187D9C8A23F23BC8F883973896C8D295D|araB]-[gene|3859854178E573AE8ACCE6DF85E32C495D316DA1|araD]-[gene|BBAD1638F435791C1846EFFAD6B6F82CE491FDF1|araL]-[gene|16EE17461B4AB467A4F8172FD3E335073AD2B1D8|araM]-[gene|C1F5D0EA21DCA5F8EC43720CDF67E859CA7B866E|araN]-[gene|8AF43CA410F3381209196E1B9A4FE66D78020793|araP]-[gene|AE532A8931D516CC676E765D1D1293E73C335D23|araQ]-[gene|2B2629D275491A9F7031D5A99BAA001B011A765B|abfA]
description
[Pubmed|9084180]
regulation
induced by arabinose ([protein|search|AraR]) [Pubmed|10417639]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12949161], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|A567466894AE9DE7CDE7816615433A37532297B5|araR]: repression, [Pubmed|10417639], in [regulon|protein:A567466894AE9DE7CDE7816615433A37532297B5|araR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084180], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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[gene|028428CE456E283C065756878EA7C7DB495DD10D|araA]→[gene|2B2629D275491A9F7031D5A99BAA001B011A765B|abfA]

2024-02-24 21:22:03

ghost

90

b7d3312ef868c449eb18db3a2b2bf36130567026

7BE2C086CD88758AEADFA2166B6FC6182EB55613

Biological materials
Mutant
MGNA-B015 (araL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1014 NBRP B. subtilis, Japan]
BKE28770 (Δ[gene|BBAD1638F435791C1846EFFAD6B6F82CE491FDF1|araL]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AATGCCAGCCGGTGACACAG,  downstream forward: _UP4_TTGGCTGAGGAGGGGATTCT
BKK28770 (Δ[gene|BBAD1638F435791C1846EFFAD6B6F82CE491FDF1|araL]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28770 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AATGCCAGCCGGTGACACAG,  downstream forward: _UP4_TTGGCTGAGGAGGGGATTCT
References
9084180,10417639,12949161,27784292

BBAD1638F435791C1846EFFAD6B6F82CE491FDF1

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Time of last update: 2024-03-28 20:15:20

Author of last update: Melvin.boenninger