YxdM

• Description: ABC transporter (permease)
  
  

Gene name	yxdM
Synonyms
Essential	no
Product	ABC transporter (permease)
Function	export of toxic peptides
MW, pI	70 kDa, 9.272
Gene length, protein length	1866 bp, 622 aa
Immediate neighbours	yxeA, yxdL
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

YxdJ regulon

The gene

Basic information

• Locus tag: BSU39630

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YxdL-YxdM PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P42424

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yxdL-yxdM-yxeA PubMed

• Sigma factor:

• Regulation:
  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) 21078927 PubMed

• Regulatory mechanism:
  • YxdJ: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Pascale Joseph, Annick Guiseppi, Alexei Sorokin, François Denizot
Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM.
Microbiology (Reading): 2004, 150(Pt 8);2609-2617
[PubMed:15289557] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)