YwpB

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  • Description: β-hydroxyacyl-(acyl carrier protein) dehydratase

Gene name ywpB
Synonyms fabZ
Essential yes PubMed
Product β-hydroxyacyl-ACP dehydratase
Function fatty acid biosynthesis
Gene expression levels in SubtiExpress: ywpB
Metabolic function and regulation of this protein in SubtiPathways:
ywpB
MW, pI 14 kDa, 9.36
Gene length, protein length 396 bp, 132 aa
Immediate neighbours mscL, rapD
Sequences Protein DNA DNA_with_flanks
Genetic context
YwpB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwpB expression.png















Categories containing this gene/protein

biosynthesis of lipids, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU36370

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: FabZ subfamily (according to Swiss-Prot)
  • Paralogous protein(s): YcsD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 3D6X (from Campylobacter jejuni, 45% identity, 67% similarity) PubMed
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Andrew S Kirkpatrick, Takeshi Yokoyama, Kyoung-Jae Choi, Hye-Jeong Yeo
Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).
Biochem Biophys Res Commun: 2009, 380(2);407-12
[PubMed:19280690] [WorldCat.org] [DOI] (I p)

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)