YwbH

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  • Description: putative holin

Gene name ywbH
Synonyms ipa-23r, cidA
Essential no
Product putative holin
Function unknown
Gene expression levels in SubtiExpress: ywbH
MW, pI 14 kDa, 9.591
Gene length, protein length 384 bp, 128 aa
Immediate neighbours ywbI, ywbG
Sequences Protein DNA DNA_with_flanks
Genetic context
YwbH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwbH expression.png
























Categories containing this gene/protein

membrane proteins, proteins of unknown function

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU38320

Phenotypes of a mutant

    • ywbHG mutant is delayed in pellicle formation (Chen et al)
    • ywbHG-yxaKC-ysbAB triple mutant is severely delayed in pellicle formation (Chen et al)
    • ywbHG overexpression strain has more robust pellicle formation (Chen et al)

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: CidA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Kelly C Rice, Ethan E Mann, Jennifer L Endres, Elizabeth C Weiss, James E Cassat, Mark S Smeltzer, Kenneth W Bayles
The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus.
Proc Natl Acad Sci U S A: 2007, 104(19);8113-8
[PubMed:17452642] [WorldCat.org] [DOI] (P p)

Kelly C Rice, Jeremy B Nelson, Toni G Patton, Soo-Jin Yang, Kenneth W Bayles
Acetic acid induces expression of the Staphylococcus aureus cidABC and lrgAB murein hydrolase regulator operons.
J Bacteriol: 2005, 187(3);813-21
[PubMed:15659658] [WorldCat.org] [DOI] (P p)