YvmC

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  • Description: cyclodipeptide synthase

Gene name yvmC
Synonyms
Essential no
Product cyclodipeptide synthase
Function biosynthesis of the extracellular iron chelate pulcherrimin
MW, pI 28 kDa, 6.612
Gene length, protein length 744 bp, 248 aa
Immediate neighbours cypX, yvmB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvmC context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

acquisition of iron, iron metabolism

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU35070

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 3S7T (from B. licheniformis, 70% identity, 86% similarity) PubMed
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Muriel Gondry, Ludovic Sauguet, Pascal Belin, Robert Thai, Rachel Amouroux, Carine Tellier, Karine Tuphile, Mickaël Jacquet, Sandrine Braud, Marie Courçon, Cédric Masson, Steven Dubois, Sylvie Lautru, Alain Lecoq, Shin-ichi Hashimoto, Roger Genet, Jean-Luc Pernodet
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
Nat Chem Biol: 2009, 5(6);414-20
[PubMed:19430487] [WorldCat.org] [DOI] (I p)

R L Uffen, E Canale-Parola
Synthesis of pulcherriminic acid by Bacillus subtilis.
J Bacteriol: 1972, 111(1);86-93
[PubMed:4204912] [WorldCat.org] [DOI] (P p)

additional paper