ytpP

ytpP
168

cleavage of CoA moieties from modified proteins, similar to thioredoxin H1

locus
BSU_29840
Molecular weight
12.61 kDa
pI
4.3
Protein length
Gene length
function
cleavage of CoA moieties from modified proteins
product
protein deCoAlase
essential
no
synonyms
ytpP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3118 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,054,188  3,054,511
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The protein
Catalyzed reaction/ biological activity
cleavage of CoA moieties from modified proteins [pubmed|37107313]
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 1-105) (according to UniProt)
Structure
[PDB|4RUV] (Thioredoxin-2 from Staphylococcus aureus, 32% identity)
[AF|O34357]
Expression and Regulation
Operons
genes
[gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]-[gene|886EF2F8A9E031FDF919E01A858C1DBC1AFF1188|ytpQ]-[gene|EE559CD606562097F09DC627F431CA31129D7BC6|ytpR]
description
[Pubmed|21949854]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|21949854], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21949854], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]→[gene|EE559CD606562097F09DC627F431CA31129D7BC6|ytpR]

2024-03-21 18:56:59

ghost

68

e3075f4343f005e46bbf1f8f6de68bdd8b77fdec

DE889C52EC07AB93CD9959D9559B3C7B78EAC111

Biological materials
Mutant
MGNA-B531 (ytpP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1530 NBRP B. subtilis, Japan]
BKE29840 ([gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29840 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCATATCCCTCCAGTT,  downstream forward: _UP4_AAAGCGTAAAGGAGGACATC
BKK29840 ([gene|314D5C01B4BDDC3B122F6D4066647B143B2A6543|ytpP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29840 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCATATCCCTCCAGTT,  downstream forward: _UP4_AAAGCGTAAAGGAGGACATC
References
21949854,37107313

314D5C01B4BDDC3B122F6D4066647B143B2A6543

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Time of last update: 2024-03-27 11:15:46

Author of last update: Jstuelk