YsnA

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  • Description: ITPase

Gene name ysnA
Synonyms
Essential no
Product ITPase
Function purine metabolism
Gene expression levels in SubtiExpress: ysnA
Metabolic function and regulation of this protein in SubtiPathways:
Thiamin
MW, pI 21 kDa, 4.95
Gene length, protein length 594 bp, 198 aa
Immediate neighbours ysnB, rph
Sequences Protein DNA DNA_with_flanks
Genetic context
YsnA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YsnA expression.png




























Categories containing this gene/protein

nucleotide metabolism/ other

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU28360

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: NTP + H2O = NDP + phosphate (according to Swiss-Prot)
  • Protein family: HAM1 NTPase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 2MJP (from Methanococcus jannaschii) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

S Lin, A G McLennan, K Ying, Z Wang, S Gu, H Jin, C Wu, W Liu, Y Yuan, R Tang, Y Xie, Y Mao
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene.
J Biol Chem: 2001, 276(22);18695-701
[PubMed:11278832] [WorldCat.org] [DOI] (P p)

K Y Hwang, J H Chung, S H Kim, Y S Han, Y Cho
Structure-based identification of a novel NTPase from Methanococcus jannaschii.
Nat Struct Biol: 1999, 6(7);691-6
[PubMed:10404228] [WorldCat.org] [DOI] (P p)