YsnA

• Description: ITPase
  
  

Gene name	ysnA
Synonyms
Essential	no
Product	ITPase
Function	purine metabolism
Metabolic function and regulation of this protein in SubtiPathways: Thiamin
MW, pI	21 kDa, 4.95
Gene length, protein length	594 bp, 198 aa
Immediate neighbours	ysnB, rph
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

nucleotide metabolism/ other

The gene

Basic information

• Locus tag: BSU28360

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: NTP + H₂O = NDP + phosphate (according to Swiss-Prot)

• Protein family: HAM1 NTPase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: http://www.pdb.org/pdb/explore/explore.do?structureId=2MJP 2MJP (from Methanococcus jannaschii) PubMed

• UniProt: P94558

• KEGG entry: [2]

• E.C. number: 3.6.1.15

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

S Lin, A G McLennan, K Ying, Z Wang, S Gu, H Jin, C Wu, W Liu, Y Yuan, R Tang, Y Xie, Y Mao
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene.
J Biol Chem: 2001, 276(22);18695-701
[PubMed:11278832] [WorldCat.org] [DOI] (P p)

K Y Hwang, J H Chung, S H Kim, Y S Han, Y Cho
Structure-based identification of a novel NTPase from Methanococcus jannaschii.
Nat Struct Biol: 1999, 6(7);691-6
[PubMed:10404228] [WorldCat.org] [DOI] (P p)