reoM

reoM
168

effector protein of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]

locus
BSU_27400
Molecular weight
10.10 kDa
pI
4.73
Protein length
Gene length
function
control of peptidoglycan biosynthesis
product
regulator of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] degradation
essential
no
synonyms
reoM, yrzL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4472 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,797,823 → 2,798,089
Phenotypes of a mutant
accumulation of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA] due to reduced degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|clpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP] [pubmed|32469310]
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The protein
Protein family
UPF0297 family (single member, according to UniProt)
Structure
[PDB|5US5] (from Enterococcus faecalis, 66% identity) [pubmed|28551334]
[PDB|6TIF] (from Listeria monocytogenes, 68% identity) [pubmed|32469310]
[AF|Q7WY61]
Expression and Regulation
Operons
genes
[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
description
[pubmed|22383849]
Open in new tab

[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]->[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]

2024-01-29 20:18:27

Bzhu

41

13604f7ff8a332a31b3eeac85d34d0390bab5a6b

A0B9F1DCCECD01642A67F9491E3DE8A7C80DD674

genes
[gene|8C5C7F9A585AE89D53EAF1DB3A9AB525B9E30B4A|alaS]-[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
description
[pubmed|22383849]
regulation
induced by alanine limitation ([regulon|T-box|]) [Pubmed|19258532]
regulatory mechanism
T-box: RNA switch, [pubmed|], in [regulon|other_regulator:T-box|T-box]
Open in new tab

[gene|8C5C7F9A585AE89D53EAF1DB3A9AB525B9E30B4A|alaS]->[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]

2024-03-19 16:38:23

Bzhu

81

1fe3dcf0db8626f9ee3da1f804086613bec215b9

F35CA2CD94C7D88BA9469B9BEE16089909E658A6

Biological materials
Mutant
BKE27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27400 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC,  downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT
BKK27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27400 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC,  downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT
References
Research papers
32469310,28551334

C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2

Page visits: 1511

Time of last update: 2024-03-28 14:15:31

Author of last update: Jstuelk