rsbRD

168

probably part of the [wiki|stressosome], negative regulator of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB] activity

locus: BSU_24760

Molecular weight: 31.66 kDa

pI: 5.09

Protein length: 278 aa

Gene length: 837 bp

function: control of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB] activity

product: [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR] paralog

essential: no

synonyms: rsbRD, yqhA

List of homologs in different organisms, belongs to COG1366 (Galperin et al., 2021)

Gene

Coordinates: 2,562,966  2,563,802

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The protein

[wiki|Domains]

• [wiki|STAS domain] (aa 160-271) (according to UniProt)

Structure

• [AF|P54504]

Modification

• phosphorylation on Thr-181 by [protein|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT] [Pubmed|21362065]

Paralogous protein(s)

• [protein|F53C527995909A1CFA72C7BF919DD10EE175C6D7|rsbRB], [protein|5EEEDE60CE9E5CDAEBAB0E03AABDF1DF62F1F002|rsbRC], [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR], [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|ytvA]

Expression and Regulation

Operons

• genes: [gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]

  description: (according to [http://dbtbs.hgc.jp/COG/prom/yqhA.html DBTBS]) null

  regulation

  • expressed under stress conditions ([protein|search|SigB]) [Pubmed|10482513,20019076]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|10482513], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]

Biological materials

Mutant

• MGNA-C475 (yqhA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2473 NBRP B. subtilis, Japan]
• BKE24760 ([gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTTAATGAGTTACCTCC,  downstream forward: _UP4_TGATGCCTTTGCCATGTTTA
• BKK24760 ([gene|979D7A45EAD97C99015029400A85795061BAA367|rsbRD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24760 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTTAATGAGTTACCTCC,  downstream forward: _UP4_TGATGCCTTTGCCATGTTTA

References

• 15312768,10482513,20019076,17726680,17218307,11157946,28271471,28727759,36409125,38236030