YqgP

• Description: intramembrane protease
  
  

Gene name	yqgP
Synonyms	glpG, gluP
Essential	no
Product	intramembrane protease
Function	cell division or sugar metabolism
Gene expression levels in SubtiExpress: yqgP
MW, pI	56 kDa, 5.507
Gene length, protein length	1521 bp, 507 aa
Immediate neighbours	yqgQ, yqgO
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, membrane proteins

The gene

Basic information

• Locus tag: BSU24870

Phenotypes of a mutant

filamentous phenotype PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains (according to Swiss-Prot)

• Protein family: peptidase S54 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms dimers PubMed

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: P54493

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yqgP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Philip Rather
Role of rhomboid proteases in bacteria.
Biochim Biophys Acta: 2013, 1828(12);2849-54
[PubMed:23518036] [WorldCat.org] [DOI] (P p)

Original publications

Padmapriya Sampathkumar, Michelle W Mak, Sarah J Fischer-Witholt, Emmanuel Guigard, Cyril M Kay, M Joanne Lemieux
Oligomeric state study of prokaryotic rhomboid proteases.
Biochim Biophys Acta: 2012, 1818(12);3090-7
[PubMed:22921757] [WorldCat.org] [DOI] (P p)

Sinisa Urban
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.
Nat Rev Microbiol: 2009, 7(6);411-23
[PubMed:19421188] [WorldCat.org] [DOI] (I p)

Lili R Mesak, Felix M Mesak, Michael K Dahl
Expression of a novel gene, gluP, is essential for normal Bacillus subtilis cell division and contributes to glucose export.
BMC Microbiol: 2004, 4;13
[PubMed:15050034] [WorldCat.org] [DOI] (I e)