sco

sco
168

accessory lipoprotein required for assembly of the Cu(A) center of [protein|72D5442C0EF3B404F7B615366E357B68C863CEB6|cytochrome c oxidase caa3]

locus
BSU_21750
Molecular weight
21.50 kDa
pI
4.81
Protein length
Gene length
function
maturation of [protein|72D5442C0EF3B404F7B615366E357B68C863CEB6|cytochrome c oxidase caa3]
product
synthesis of cytochrome oxidase protein
essential
no
synonyms
sco, ypmQ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1999 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,291,703  2,292,284
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The protein
Catalyzed reaction/ biological activity
electron transfer to the maturing oxidase [protein|72D5442C0EF3B404F7B615366E357B68C863CEB6|cytochrome c oxidase caa3] [Pubmed|19921776]
Protein family
SCO1/2 family (single member, according to UniProt)
[wiki|Domains]
[wiki|Thioredoxin domain] (aa 26-191) (according to UniProt)
[wiki|Cofactors]
contains copper bound by two cysteines and a histidine residue [Pubmed|19921776]
Structure
[PDB|1XZO] [pubmed|15723536]
[AF|P54178]
[wiki|Localization]
lipoprotein, cell membrane  [Pubmed|19921776]
Expression and Regulation
Operons
genes
[gene|0337C7B1CFA1C59710A7E6463A370F8C39AAC8EA|sco]-[gene|4722C78DB10289939145BDD079661021160C688C|ypmR]-[gene|6E668E7BCD26FCC9873D538385DAF851D7CEC8FC|ypmS]-[gene|3EDC7B00A30AA32E0F8D4FB40011A4BF08B1AB18|ypmT]
description
[Pubmed|22383849]
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[gene|0337C7B1CFA1C59710A7E6463A370F8C39AAC8EA|sco]→[gene|3EDC7B00A30AA32E0F8D4FB40011A4BF08B1AB18|ypmT]

2024-03-03 12:43:49

Jstuelk

51

d6ed3f20fd38bd7de55cce984764b26af8247cef

00F66E27C368E90AECAEFEEDCBB05239029A914C

Biological materials
Mutant
MGNA-A882 (ypmQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/882 NBRP B. subtilis, Japan]
BKE21750 ([gene|0337C7B1CFA1C59710A7E6463A370F8C39AAC8EA|sco]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21750 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGACATCCATCCTTTCCA,  downstream forward: _UP4_TAAGCTAAGAGACTAGGCAT
BKK21750 ([gene|0337C7B1CFA1C59710A7E6463A370F8C39AAC8EA|sco]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21750 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGACATCCATCCTTTCCA,  downstream forward: _UP4_TAAGCTAAGAGACTAGGCAT
Reviews
35630371
References
14680962,14766920,16305244,19027886,10837475,19921776,20232870,21333651,21945854,22036877,25192666,21069401,15723536,29131589,12832793,29676768

0337C7B1CFA1C59710A7E6463A370F8C39AAC8EA

Page visits: 2372

Time of last update: 2024-03-28 13:28:49

Author of last update: Jstuelk