prsW

168

protease, cleaves [protein|4E720917045032E8B45CB8AF6E5C13AE0E48EE33|rsiW] in the presence of antimicrobial peptides

locus: BSU_22940

Molecular weight: 24.57 kDa

pI: 8.09

Protein length: 218 aa

Gene length: 657 bp

function: control of [wiki|SigW] activity

product: protease

essential: no

synonyms: prsW, ypdC

List of homologs in different organisms, belongs to COG2339 (Galperin et al., 2021)

Gene

Coordinates: 2,400,208 → 2,400,864

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The protein

Protein family

• protease prsW family (single member, according to UniProt)

Structure

• [AF|P50738]

[wiki|Localization]

• membrane [Pubmed|17020587]

Expression and Regulation

Operons

• genes: [gene|EE3B6B52EA19958E2E46A1545747F5209A6AA036|prsW]

  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-A418 (ypdC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/418 NBRP B. subtilis, Japan]
• BKE22940 (Δ[gene|EE3B6B52EA19958E2E46A1545747F5209A6AA036|prsW]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22940 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCAACCTCTTTCCT,  downstream forward: _UP4_TAGAAGCCGCACAGCAACCG
• BKK22940 (Δ[gene|EE3B6B52EA19958E2E46A1545747F5209A6AA036|prsW]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22940 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCAACCTCTTTCCT,  downstream forward: _UP4_TAGAAGCCGCACAGCAACCG

labs

• [wiki|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas%20Wiegert-Dateien/Thomas%20Wiegert.html Homepage]

References

Reviews

• 22688815,23479438,22381678,29343670,34410368

Original Publications

• 16816000,17020587,19889088,23155385