YpbH

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  • Description: putative adaptor protein for ClpC-ClpP

Gene name ypbH
Synonyms
Essential no
Product putative adaptor protein
Function unknown
Gene expression levels in SubtiExpress: ypbH
Interactions involving this protein in SubtInteract: YpbH
MW, pI 22 kDa, 4.095
Gene length, protein length 582 bp, 194 aa
Immediate neighbours gudB, ypbG
Gene sequence (+200bp) Protein sequence
Genetic context
YpbH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YpbH expression.png















Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22970

Phenotypes of a mutant

deletion reduces sporulation to 20%, overexpression abolishes sporulation PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): MecA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • low expression, enhanced in stat phase in LB or competence but not in sporulation medium PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP812 (spc), GP814 (spc) both available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Additional reviews: PubMed

Aurelia Battesti, Susan Gottesman
Roles of adaptor proteins in regulation of bacterial proteolysis.
Curr Opin Microbiol: 2013, 16(2);140-7
[PubMed:23375660] [WorldCat.org] [DOI] (I p)


Original Publications

Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Siheng Xiang, Zhiyuan Zhou, Qi Hu, Jiawei Wang, Yigong Shi
Crystal structure of the MecA degradation tag.
J Biol Chem: 2009, 284(49);34376-81
[PubMed:19801546] [WorldCat.org] [DOI] (I p)

Marjan Persuh, Ines Mandic-Mulec, David Dubnau
A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
J Bacteriol: 2002, 184(8);2310-3
[PubMed:11914365] [WorldCat.org] [DOI] (P p)