Difference between revisions of "YmcA"
| Line 1: | Line 1: | ||
| − | * '''Description:''' antagonist of biofilm repression by [[SinR]] <br/><br/> | + | * '''Description:''' antagonist of biofilm repression by [[SinR]], control of the [[phosphorelay]] <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || antagonist of biofilm repression by [[SinR]] | |style="background:#ABCDEF;" align="center"| '''Product''' || antagonist of biofilm repression by [[SinR]] | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]] | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]] and the [[phosphorelay]] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU17020 ymcA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU17020 ymcA] | ||
| Line 53: | Line 53: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * strongly reduced [[genetic competence]], strongly reduced [[sporulation]] {{PubMed|23490197}} | ||
=== Database entries === | === Database entries === | ||
| Line 89: | Line 90: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** [[YmcA]]-[[YlbF]]-[[YaaT]], this complex stimulates [[Spo0A]] phosphorylation in the [[phosphorelay]] {{PubMed|23490197}} | ** [[YmcA]]-[[YlbF]]-[[YaaT]], this complex stimulates [[Spo0A]] phosphorylation in the [[phosphorelay]] {{PubMed|23490197}} | ||
| + | ** [[YmcA]]-[[Spo0B]] {{PubMed|23490197}} | ||
| + | ** [[YmcA]]-[[Spo0F]] {{PubMed|23490197}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| Line 113: | Line 116: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** expressed during growth and the transition phase, expression is erduced in stationary phase ([[Spo0A]]-P) {{PubMed|23490197}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 14:02, 27 March 2013
- Description: antagonist of biofilm repression by SinR, control of the phosphorelay
| Gene name | ymcA |
| Synonyms | |
| Essential | no |
| Product | antagonist of biofilm repression by SinR |
| Function | control of biofilm formation and the phosphorelay |
| Gene expression levels in SubtiExpress: ymcA | |
| Interactions involving this protein in SubtInteract: YmcA | |
| MW, pI | 16 kDa, 5.086 |
| Gene length, protein length | 429 bp, 143 aa |
| Immediate neighbours | ymcB, cotE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, biofilm formation
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17020
Phenotypes of a mutant
- strongly reduced genetic competence, strongly reduced sporulation PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2PIH
- UniProt: O31779
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Valerie J Carabetta, Andrew W Tanner, Todd M Greco, Melissa Defrancesco, Ileana M Cristea, David Dubnau
A complex of YlbF, YmcA and YaaT regulates sporulation, competence and biofilm formation by accelerating the phosphorylation of Spo0A.
Mol Microbiol: 2013, 88(2);283-300
[PubMed:23490197]
[WorldCat.org]
[DOI]
(I p)
Daniel B Kearns, Frances Chu, Steven S Branda, Roberto Kolter, Richard Losick
A master regulator for biofilm formation by Bacillus subtilis.
Mol Microbiol: 2005, 55(3);739-49
[PubMed:15661000]
[WorldCat.org]
[DOI]
(P p)
Steven S Branda, José Eduardo González-Pastor, Etienne Dervyn, S Dusko Ehrlich, Richard Losick, Roberto Kolter
Genes involved in formation of structured multicellular communities by Bacillus subtilis.
J Bacteriol: 2004, 186(12);3970-9
[PubMed:15175311]
[WorldCat.org]
[DOI]
(P p)
