YkwC
- Description: putative beta-hydroxyacid dehydrogenase
| Gene name | ykwC |
| Synonyms | |
| Essential | no |
| Product | putative beta-hydroxyacid dehydrogenase |
| Function | unknown |
| Gene expression levels in SubtiExpress: ykwC | |
| MW, pI | 30 kDa, 5.109 |
| Gene length, protein length | 864 bp, 288 aa |
| Immediate neighbours | mcpC, ykwD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
poorly characterized/ putative enzymes, most abundant proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13960
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: 3-hydroxyisobutyrate dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s): YfjR
Extended information on the protein
- Kinetic information:
- Modification: phosphorylated on Ser-281 by PrkC, dephosphorylated by PrpC, phosphorylation abolishes the oxidoreductase activity of YkwC in vitro and in vivo PubMed
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O34948
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
- belongs to the 100 most abundant proteins PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Vaishnavi Ravikumar, Lei Shi, Karsten Krug, Abderahmane Derouiche, Carsten Jers, Charlotte Cousin, Ahasanul Kobir, Ivan Mijakovic, Boris Macek
Quantitative phosphoproteome analysis of Bacillus subtilis reveals novel substrates of the kinase PrkC and phosphatase PrpC.
Mol Cell Proteomics: 2014, 13(8);1965-78
[PubMed:24390483]
[WorldCat.org]
[DOI]
(I p)
Christine Eymann, Annette Dreisbach, Dirk Albrecht, Jörg Bernhardt, Dörte Becher, Sandy Gentner, Le Thi Tam, Knut Büttner, Gerrit Buurman, Christian Scharf, Simone Venz, Uwe Völker, Michael Hecker
A comprehensive proteome map of growing Bacillus subtilis cells.
Proteomics: 2004, 4(10);2849-76
[PubMed:15378759]
[WorldCat.org]
[DOI]
(P p)
