YkuI

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  • Description: c-di-GMP specific phosphodiesterase

Gene name ykuI
Synonyms
Essential no
Product c-di-GMP specific phosphodiesterase
Function unknown
MW, pI 47 kDa, 4.462
Gene length, protein length 1221 bp, 407 aa
Immediate neighbours ykuH, fsrA
Gene sequence (+200bp) Protein sequence
Genetic context
YkuI context.gif



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: degradation of cyclic di-GMP PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: EAL domain (aa 1 ... 245, for c-di-GMP hydrolysis), PAS-like domain (aa 300 ... 400) PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Swiss prot entry:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Minasov et al. (2009) Crystal structures of YkuI and its complex with second messenger c-di-GMP suggests catalytic mechanism of phosphodiester bond cleavage by EAL domains J. Biol. Chem volume: page-page. PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed