ohrA

168

peroxiredoxin , protects the cell against organic peroxides

locus: BSU_13140

Molecular weight: 14.73 kDa

pI: 5.06

Protein length: 141 aa

Gene length: 426 bp

function: organic peroxide resistance

product: peroxiredoxin

essential: no

synonyms: ohrA, yklA

List of homologs in different organisms, belongs to COG1764 (Galperin et al., 2021)

Gene

Coordinates: 1,380,978  1,381,403

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The protein

Protein family

• osmC/ohr family (with [protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB] and [protein|0785B4C70C3DD00EFB8BCDD91EF4F98EF4372186|ymaD], according to UniProt)

Structure

• [PDB|2BJO] ([protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB], 51% identity) [pubmed|18084074]
• [AF|O34762]

Paralogous protein(s)

• [protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB]

Expression and Regulation

Operons

• genes: [gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]

  description: [Pubmed|9696771]

  regulation

  • induced by organic peroxides ([protein|search|OhrR]) [Pubmed|11418552]

  regulatory mechanism

  • [protein|7A3A8AF7728474204396BB7A548F747D28E6FAC7|ohrR]: repression, [Pubmed|11418552], in [regulon|protein:7A3A8AF7728474204396BB7A548F747D28E6FAC7|ohrR regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9696771], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

Biological materials

Mutant

• GP1727 [gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::tet trpC2 available in [wiki|Jörg Stülke]'s lab
• MGNA-A749 (yklA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/749 NBRP B. subtilis, Japan]
• BKE13140 ([gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTTCATTCCCCCAATA,  downstream forward: _UP4_TAAATAAAAAGAGGATGCCT
• BKK13140 ([gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTTCATTCCCCCAATA,  downstream forward: _UP4_TAAATAAAAAGAGGATGCCT

References

• 16209951,12486061,11418552,9696771,18084074