ykfC

ykfC
168

D-glutamyl-L-amino acid peptidase

locus
BSU_12990
Molecular weight
32.91 kDa
pI
6.35
Protein length
Gene length
function
cell wall metabolism
product
D-glutamyl-L-amino acid peptidase
essential
no
synonyms
ykfC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0791 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,367,941 → 1,368,831
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The protein
Catalyzed reaction/ biological activity
cleaves L-Ala-γ-D-Glu dipeptides from cell wall peptides [Pubmed|20944232]
The enzyme releases L-Ala-gamma-D-Glu dipeptides from cell wall peptides via cleavage of an L-Ala-gamma-D-Glu-|-L-Lys bond (according to UniProt)
Protein family
[wiki|Peptidase C40 family] (according to UniProt)
Structure
[PDB|3H41] (from B. cereus, 39% identity) [pubmed|20944232]
[AF|O35010]
Expression and Regulation
Operons
genes
[gene|9E922F0006DF9E84A8D5B51E9FC35B669872FF90|dppA]-[gene|062AE5FB4C778178A7F6833CB8BD9D631E461E89|dppB]-[gene|EDF8D2C49FA5552B24135E12524F9035E1E01473|dppC]-[gene|7FA72D949B930A3C7FF0391CC6CCC58EEFCA839A|dppD]-[gene|853C570CFB9382449A20BE77B44B4FE44972AA59|dppE]-[gene|C4F85F85F0C99A59145961E34B19D3AD03D2BC22|ykfA]-[gene|77EFC47449D8CC17651ED61C41AC605FCEF01270|ykfB]-[gene|D40ECAE51D9E4791C6FAAA25E2E0D0591D9FAA55|ykfC]-[gene|BB94F5388A0D1FF025E5A88A7E10AE7E4C489E5F|ykfD]
description
[pubmed|22383849]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|12618455], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
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[gene|9E922F0006DF9E84A8D5B51E9FC35B669872FF90|dppA]->[gene|BB94F5388A0D1FF025E5A88A7E10AE7E4C489E5F|ykfD]

2024-03-12 10:58:41

Bzhu

85

9978370314fc05087eca13c4f3ce94e92ce93ff2

E2A0CC9BE866DBD9F0E3A5F48EE05465C14EFD9D

Biological materials
Mutant
MGNA-A742 (ykfC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/742 NBRP B. subtilis, Japan]
BKE12990 (Δ[gene|D40ECAE51D9E4791C6FAAA25E2E0D0591D9FAA55|ykfC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12990 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTGCTGATATGACAGTGT,  downstream forward: _UP4_TTTTCAGAATAAGGAGGGAG
BKK12990 (Δ[gene|D40ECAE51D9E4791C6FAAA25E2E0D0591D9FAA55|ykfC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12990 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTGCTGATATGACAGTGT,  downstream forward: _UP4_TTTTCAGAATAAGGAGGGAG
References
12618455,20944232

D40ECAE51D9E4791C6FAAA25E2E0D0591D9FAA55

Page visits: 1644

Time of last update: 2024-03-28 05:07:45

Author of last update: Melvin.boenninger