Difference between revisions of "YisP"

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* '''Description:''' production of squalene-derived polyisoprenoids <br/><br/>
+
* '''Description:''' farnesyl diphosphate phosphatase, production of farnesol <br/><br/>
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || squalene synthase
+
|style="background:#ABCDEF;" align="center"| '''Product''' || farnesyl diphosphate phosphatase
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[KinC]] activity
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[KinC]] activity
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* complete loss of pellicle-forming ability {{PubMed|20713508}}
 
* complete loss of pellicle-forming ability {{PubMed|20713508}}
 
* reduced [[protein secretion]] {{PubMed|23651456}}
 
* reduced [[protein secretion]] {{PubMed|23651456}}
 +
 
=== Database entries ===
 
=== Database entries ===
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU10810&redirect=T BSU10810]
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU10810&redirect=T BSU10810]
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 +
** farnesyl diphosphate --> farnesol {{PubMed|25308276}}
  
 
* '''Protein family:'''
 
* '''Protein family:'''
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* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU10810&redirect=T BSU10810]
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU10810&redirect=T BSU10810]
  
* '''Structure:'''
+
* '''Structure:''' [http://pdb.org/pdb/explore/explore.do?structureId=3WE9 3WE9] {{PubMed|25308276}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O06728 O06728]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O06728 O06728]
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=== Additional information===
 
=== Additional information===
The gene is annotated in KEGG as an ortholog of phytoene synthase EC 2.5.1.32. No EC annotation is available in Swiss-Prot/MetaCSwiss-Prot/MetaCyc.literature/experimental evidence supporting the annotation is available. {{PubMed|19935659}}
+
 
  
 
=Expression and regulation=
 
=Expression and regulation=
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=References=
 
=References=
  
<pubmed> 20713508 19935659 23651456 23295493</pubmed>
+
<pubmed> 20713508 19935659 23651456 23295493 25308276 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 08:05, 14 October 2014

  • Description: farnesyl diphosphate phosphatase, production of farnesol

Gene name yisP
Synonyms yucD
Essential no
Product farnesyl diphosphate phosphatase
Function control of KinC activity
Gene expression levels in SubtiExpress: yisP
MW, pI 31 kDa, 7.258
Gene length, protein length 822 bp, 274 aa
Immediate neighbours yizA, yisQ
Sequences Protein DNA DNA_with_flanks
Genetic context
YisP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YisP expression.png















Categories containing this gene/protein

biosynthesis of lipids, phosphorelay, biofilm formation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU10810

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • farnesyl diphosphate --> farnesol PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 37 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References