YhfU

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  • Description: high capacity biotin transporter

Gene name yhfU
Synonyms bioY
Essential no
Product high capacity biotin transporter
Function uptake of biotin
Gene expression levels in SubtiExpress: yhfU
MW, pI 19 kDa, 10.681
Gene length, protein length 558 bp, 186 aa
Immediate neighbours yhfT, hemAT
Sequences Protein DNA DNA_with_flanks
Genetic context
YhfU context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YhfU expression.png
























Categories containing this gene/protein

transporters/ other, biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU10370

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: uptake of biotin PubMed
  • Protein family: bioY family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Steven Lin, John E Cronan
Closing in on complete pathways of biotin biosynthesis.
Mol Biosyst: 2011, 7(6);1811-21
[PubMed:21437340] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Original publications

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Peter Hebbeln, Dmitry A Rodionov, Anja Alfandega, Thomas Eitinger
Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module.
Proc Natl Acad Sci U S A: 2007, 104(8);2909-14
[PubMed:17301237] [WorldCat.org] [DOI] (P p)