tcyP

tcyP
168

cystine and diaminopimelate transporter

locus
BSU_09130
Molecular weight
48.82 kDa
pI
9.47
Protein length
Gene length
function
cystine and diaminopimelate uptake
product
cystine and diaminopimelate transporter
essential
no
synonyms
tcyP, yhcL

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1823 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
986,986 → 988,377
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The protein
Catalyzed reaction/ biological activity
cystine-proton symporter [Pubmed|15262924]
transport of diaminopimelate [pubmed|29995990]
Protein family
[wiki|dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family] (according to UniProt)
Structure
[PDB|3KBC] (from ''Pyrococcus horikoshii'', 28% identity) [Pubmed|19924125]
[AF|P54596]
Kinetic information
K(m) = 0.6 myM cystine [Pubmed|15262924]
[wiki|Localization]
membrane associated [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|EC287BBD7AB1EB44A33BF29144448F53D06AC6D9|tcyP]
regulation
repressed in the presence of sulfate or cysteine ([protein|search|CymR]) [Pubmed|16513748]
regulatory mechanism
[protein|50930C56C27D22715620A350220E3C56ADB41020|cymR]: repression, [Pubmed|16513748], in [regulon|protein:50930C56C27D22715620A350220E3C56ADB41020|cymR regulon]
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[gene|EC287BBD7AB1EB44A33BF29144448F53D06AC6D9|tcyP]

2024-03-14 21:10:13

ghost

52

5ea1d8626a0599a33a06a2dd344d1eb12bf3becd

1498CA448F071BF799C224B19965903939D1377D

Biological materials
Mutant
MGNA-A657 (yhcL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/657 NBRP B. subtilis, Japan]
1A949 ( ''tcyP''::''spec''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A949&Search=1A949 BGSC]
BKE09130 (Δ[gene|EC287BBD7AB1EB44A33BF29144448F53D06AC6D9|tcyP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAGGTAAACTCTCCC,  downstream forward: _UP4_TAACATATGAAAACGTGTAA
BKK09130 (Δ[gene|EC287BBD7AB1EB44A33BF29144448F53D06AC6D9|tcyP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAGGTAAACTCTCCC,  downstream forward: _UP4_TAACATATGAAAACGTGTAA
labs
[[Isabelle Martin-Verstraete]], Institute Pasteur, Paris, France
References
15262924,12193636,16513748,16513748,18763711,19924125,29995990

EC287BBD7AB1EB44A33BF29144448F53D06AC6D9

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Time of last update: 2024-03-28 01:42:38

Author of last update: Jstuelk