yfmK

168

Nε-lysine acetyltransferase, acetylation of the histone-like protein [protein|EFD8FC875B6787B1512C5FC4C81E7E4C9BD93028|HBsu]

locus: BSU_07440

Molecular weight: 17.17 kDa

pI: 4.35

Protein length: 148 aa

Gene length: 447 bp

function: acetylation of the histone-like protein [protein|EFD8FC875B6787B1512C5FC4C81E7E4C9BD93028|HBsu], regulation of nucleoid compaction

product: Nε-lysine acetyltransferase

essential: no

synonyms: yfmK

List of homologs in different organisms, belongs to COG1247 (Galperin et al., 2021)

Gene

Coordinates: 817,311  817,757

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The protein

Catalyzed reaction/ biological activity

• acetylation of [protein|EFD8FC875B6787B1512C5FC4C81E7E4C9BD93028|HBsu] on Lys-80, probably also on Lys-3, Lys-18, and Lys-41 [pubmed|30808761]

Protein family

• [wiki|Acetyltransferase family] (according to UniProt)

[wiki|Domains]

• [wiki|N-acetyltransferase domain] (aa 8-148) (according to UniProt)

Structure

• [AF|O34536]

Expression and Regulation

Operons

• genes: [gene|0E6564B1B910694F28FD6EF5231E6F6A0E4BE545|yfmK]

  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-C240 (yfmK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2238 NBRP B. subtilis, Japan]
• BKE07440 ([gene|0E6564B1B910694F28FD6EF5231E6F6A0E4BE545|yfmK]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCCCACCTCCGCGCA,  downstream forward: _UP4_TGATCTCATCGAAACACAAA
• BKK07440 ([gene|0E6564B1B910694F28FD6EF5231E6F6A0E4BE545|yfmK]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCCCACCTCCGCGCA,  downstream forward: _UP4_TGATCTCATCGAAACACAAA

References

Research papers

• 30808761