Difference between revisions of "YcnK"

From SubtiWiki
Jump to: navigation, search
Line 1: Line 1:
* '''Description:''' transcription repressor of  the ''[[ycnJ]]'' gene <br/><br/>
+
* '''Description:''' transcription repressor of  the ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' operon <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
Line 35: Line 35:
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
 
 
 
<br/><br/>
 
<br/><br/>
  
Line 66: Line 62:
  
 
=== Additional information===
 
=== Additional information===
 
 
  
  
Line 110: Line 104:
 
=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''ycnK'' (according to [http://dbtbs.hgc.jp/COG/prom/ycnK.html DBTBS])
+
* '''Operon:''' ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' {{PubMed|22904286,22383849}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ycnK_448461_449033_-1 ycnK] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ycnK_448461_449033_-1 ycnK] {{PubMed|22383849}}
Line 146: Line 140:
 
=References=
 
=References=
  
<pubmed>19168619,,15101989,, </pubmed>
+
<pubmed>19168619,22904286,22383849,15101989,, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:22, 22 August 2012

  • Description: transcription repressor of the ycnK-ycnJ-ycnI operon

Gene name ycnK
Synonyms
Essential no
Product transcription repressor
Function regulation of copper uptake
Gene expression levels in SubtiExpress: ycnK
MW, pI 21 kDa, 7.371
Gene length, protein length 570 bp, 190 aa
Immediate neighbours ycnJ, ycnL
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YcnK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YcnK expression.png















Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control

This gene is a member of the following regulons

AbrB regulon

The YcnK regulon:

The gene

Basic information

  • Locus tag: BSU03960

Phenotypes of a mutant

elevated expression of ycnJ under conditions of copper excess PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: repression of ycnJ expression PubMed
  • Protein family: DeoR family of transcription factors
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): copper acts as corepressor PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Kazutake Hirooka, Takayosh Edahiro, Kosuke Kimura, Yasutaro Fujita
Direct and indirect regulation of the ycnKJI operon involved in copper uptake through two transcriptional repressors, YcnK and CsoR, in Bacillus subtilis.
J Bacteriol: 2012, 194(20);5675-87
[PubMed:22904286] [WorldCat.org] [DOI] (I p)

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)

Shashi Chillappagari, Marcus Miethke, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
J Bacteriol: 2009, 191(7);2362-70
[PubMed:19168619] [WorldCat.org] [DOI] (I p)

Mélanie A Hamon, Nicola R Stanley, Robert A Britton, Alan D Grossman, Beth A Lazazzera
Identification of AbrB-regulated genes involved in biofilm formation by Bacillus subtilis.
Mol Microbiol: 2004, 52(3);847-60
[PubMed:15101989] [WorldCat.org] [DOI] (P p)