YcbH

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  • Description: galactarate dehydratase

Gene name ycbH
Synonyms garD
Essential no
Product galactarate dehydratase
Function galactarate utilization
Gene expression levels in SubtiExpress: ycbH
MW, pI 54 kDa, 5.705
Gene length, protein length 1530 bp, 510 aa
Immediate neighbours ycbG, ycbJ
Sequences Protein DNA DNA_with_flanks
Genetic context
YcbH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YcbH expression.png
























Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

YcbG regulon

The gene

Basic information

  • Locus tag: BSU02510

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: d-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O (according to Swiss-Prot)
  • Protein family: uxaA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: induced by D-glucarate/galactarate (YcbG) PubMed
  • Regulatory mechanism: YcbG: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Shigeo Hosoya, Kunio Yamane, Michio Takeuchi, Tsutomu Sato
Identification and characterization of the Bacillus subtilis D-glucarate/galactarate utilization operon ycbCDEFGHJ.
FEMS Microbiol Lett: 2002, 210(2);193-9
[PubMed:12044674] [WorldCat.org] [DOI] (P p)