YcbH

• Description: galactarate dehydratase
  
  

Gene name	ycbH
Synonyms	garD
Essential	no
Product	galactarate dehydratase
Function	galactarate utilization
MW, pI	54 kDa, 5.705
Gene length, protein length	1530 bp, 510 aa
Immediate neighbours	ycbG, ycbJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

YcbG regulon

The gene

Basic information

• Locus tag: BSU02510

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: d-galactarate = 5-dehydro-4-deoxy-D-glucarate + H₂O (according to Swiss-Prot)

• Protein family: uxaA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P42240

• KEGG entry: [3]

• E.C. number: 4.2.1.42

Expression and regulation

• Operon: ycbC-ycbD-ycbE-ycbF-ycbG-ycbH-ycbJ PubMed

• Sigma factor:

• Regulation: induced by D-glucarate/galactarate (YcbG) PubMed

• Regulatory mechanism: YcbG: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Shigeo Hosoya, Kunio Yamane, Michio Takeuchi, Tsutomu Sato
Identification and characterization of the Bacillus subtilis D-glucarate/galactarate utilization operon ycbCDEFGHJ.
FEMS Microbiol Lett: 2002, 210(2);193-9
[PubMed:12044674] [WorldCat.org] [DOI] (P p)