aimA

aimA
168

general amino acid importer, low affinity symporter for glutamate/H+, serine/H+, asparagine/H+, glycine/H+, 2,3-diaminopropionic acid/H+, alanine/H+, and ß-alanine/H+

locus
BSU_02120
Molecular weight
59.03 kDa
pI
9.82
Protein length
Gene length
function
low affinity uptake of serine, glutamate, asparagine, glycine, alanine, and ß-alanine
product
amino acid importer A
essential
no
synonyms
aimA, ybeC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0531 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
231,348  232,967
Phenotypes of a mutant
resistant to serine [pubmed|32743959]
inactivation of [gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA] facilitates the adaptation a strain lacking c-di-AMP to growth on medium containing glutamate [pubmed|33481774]
a [gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA] [gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB] [gene|210C83EBEBD3DE4946BC511E0249D0032A7CE3D0|bcaP] triple mutant is resistant to 2,3-diaminopropionic acid [pubmed|38470260]
a [gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA] [gene|219586A3F378DC38EA076FD39B99D41136BDE722|alaP] double mutant is resistant to L-alanine [pubmed|38470260]
a [gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA] [gene|219586A3F378DC38EA076FD39B99D41136BDE722|alaP] double mutant is resistant to ß-alanine [pubmed|38470260]
a [gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA] mutant is resistant to glycine [pubmed|38470260]
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The protein
Catalyzed reaction/ biological activity
uptake of serine [pubmed|32743959], glutamate [pubmed|33481774], asparagine [pubmed|38193659], glycine [pubmed|38470260], diaminopropionic acid [pubmed|38470260], alanine [pubmed|38470260], and ß-alanine [pubmed|38470260] (symport with H+)
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
Structure
[PDB|6F2G] from Carnobacterium sp. AT7, 24.8% identity [pubmed|31000719]
[AF|Q45577]
Kinetic information
KS for glutamate:
- 3.2 mM (at external KCl concentration of 0.1 mM) [pubmed|33481774]
- 2.3 mM (at external KCl concentration of 5 mM) [pubmed|33481774]
Paralogous protein(s)
[protein|3AC4ED647836A1633DC3439BB4F3A74FA78CF2DB|yveA]
[wiki|Localization]
membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]
description
[pubmed|22383849]
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[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]

2024-03-24 02:00:00

Jstuelk

61

8f40d54a7334ab08a66bf016722ed7a524f88cba

EF7CE6EB8D305959A532B33D648B0415F0C68903

Biological materials
Mutant
GP3590 (Δ[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]::''phleo''), available in [wiki|Jörg Stülke]'s lab [pubmed|38193659]
GP1886 Δ[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]::cat, available in [wiki|Jörg Stülke]'s lab [pubmed|32743959]
GP2786 Δ[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]::aphA3, available in [wiki|Jörg Stülke]'s lab [pubmed|32743959]
MGNA-B963 (ybeC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1962 NBRP B. subtilis, Japan]
BKE02120 ([gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02120 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCGTAAACACCTTTCA,  downstream forward: _UP4_TAAAATATAGAAGAAAACCT
BKK02120 ([gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02120 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCGTAAACACCTTTCA,  downstream forward: _UP4_TAAAATATAGAAGAAAACCT
GP2831 (''Δ''''[gene|533EEB1A454D29800C9A00A0BE107ECEE2138DAB|gltT]''::''aphA3'' ''Δ''''[gene|151A61315ADAA7213502F15C0C0ED636A4C3EA7C|aimA]''::''phleo''), available in [wiki|Jörg Stülke]'s lab
FLAG-tag construct
GP3062 ''ybeC-3xFLAG spc'' (based on [wiki|pGP1331]), available in [wiki|Jörg Stülke]'s lab
lacZ fusion
pGP2287 (in [wiki|pAC5]) (GP2965), available in [wiki|Jörg Stülke]'s lab [pubmed|32743959]
References
18763711,31000719,32743959,33481774,38193659,38470260

151A61315ADAA7213502F15C0C0ED636A4C3EA7C

Page visits: 4502

Time of last update: 2024-03-28 09:09:58

Author of last update: Jstuelk