YabM

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  • Description: may function in a previously observed alternate pathway for peptidoglycan strand synthesis

Gene name yabM
Synonyms
Essential no
Product unknown
Function alternate pathway for peptidoglycan strand synthesis
Gene expression levels in SubtiExpress: yabM
MW, pI 57 kDa, 9.623
Gene length, protein length 1596 bp, 532 aa
Immediate neighbours spoVT, yabN
Sequences Protein DNA DNA_with_flanks
Genetic context
YabM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YabM expression.png
























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00570

Phenotypes of a mutant

Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins. PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed
  • Protein family: polysaccharide synthase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Allison Fay, Jonathan Dworkin
Bacillus subtilis homologs of MviN (MurJ), the putative Escherichia coli lipid II flippase, are not essential for growth.
J Bacteriol: 2009, 191(19);6020-8
[PubMed:19666716] [WorldCat.org] [DOI] (I p)

Pradeep Vasudevan, Jessica McElligott, Christa Attkisson, Michael Betteken, David L Popham
Homologues of the Bacillus subtilis SpoVB protein are involved in cell wall metabolism.
J Bacteriol: 2009, 191(19);6012-9
[PubMed:19648239] [WorldCat.org] [DOI] (I p)

Kei Asai, Hiromu Takamatsu, Megumi Iwano, Takeko Kodama, Kazuhito Watabe, Naotake Ogasawara
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
Microbiology (Reading): 2001, 147(Pt 4);919-927
[PubMed:11283287] [WorldCat.org] [DOI] (P p)