Difference between revisions of "YabM"

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(References)
(Phenotypes of a mutant)
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
  
Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins. {{PubMed|19648239}}
+
Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A [[penicillin-binding proteins]]. {{PubMed|19648239}}
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 12:33, 18 November 2009

  • Description: may function in a previously observed alternate pathway for peptidoglycan strand synthesis

Gene name yabM
Synonyms
Essential no
Product unknown
Function alternate pathway for peptidoglycan strand synthesis
MW, pI 57 kDa, 9.623
Gene length, protein length 1596 bp, 532 aa
Immediate neighbours spoVT, yabN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YabM context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU00570

Phenotypes of a mutant

Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins. PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed
  • Protein family: polysaccharide synthase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Allison Fay, Jonathan Dworkin
Bacillus subtilis homologs of MviN (MurJ), the putative Escherichia coli lipid II flippase, are not essential for growth.
J Bacteriol: 2009, 191(19);6020-8
[PubMed:19666716] [WorldCat.org] [DOI] (I p)

Pradeep Vasudevan, Jessica McElligott, Christa Attkisson, Michael Betteken, David L Popham
Homologues of the Bacillus subtilis SpoVB protein are involved in cell wall metabolism.
J Bacteriol: 2009, 191(19);6012-9
[PubMed:19648239] [WorldCat.org] [DOI] (I p)

Kei Asai, Hiromu Takamatsu, Megumi Iwano, Takeko Kodama, Kazuhito Watabe, Naotake Ogasawara
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
Microbiology (Reading): 2001, 147(Pt 4);919-927
[PubMed:11283287] [WorldCat.org] [DOI] (P p)