YabJ

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  • Description: required for activity of PurR

Gene name yabJ
Synonyms
Essential no
Product unknown
Function regulation of purine biosynthesis
Gene expression levels in SubtiExpress: yabJ
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 13 kDa, 5.134
Gene length, protein length 375 bp, 125 aa
Immediate neighbours purR, spoVG
Sequences Protein DNA Advanced_DNA
Genetic context
YabJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YabJ expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, transcription factors and their control

This gene is a member of the following regulons

PurR regulon

The gene

Basic information

  • Locus tag: BSU00480

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Ref.3 (according to Swiss-Prot) YjgF family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: negative autoregulation PubMed
    • repressed in the presence of purine nucleotides (PurR) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

S Sinha, P Rappu, S C Lange, P Mäntsälä, H Zalkin, J L Smith
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family.
Proc Natl Acad Sci U S A: 1999, 96(23);13074-9
[PubMed:10557275] [WorldCat.org] [DOI] (P p)

P Rappu, B S Shin, H Zalkin, P Mäntsälä
A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor.
J Bacteriol: 1999, 181(12);3810-5
[PubMed:10368157] [WorldCat.org] [DOI] (P p)

M Weng, P L Nagy, H Zalkin
Identification of the Bacillus subtilis pur operon repressor.
Proc Natl Acad Sci U S A: 1995, 92(16);7455-9
[PubMed:7638212] [WorldCat.org] [DOI] (P p)