YabA

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• Description: tethers DnaA to the polymerase-clamp protein DnaN <br/><br/>

Gene name	yabA
Synonyms
Essential	no
Product	negative regulator of replication initiation
Function	positioning of DnaA
MW, pI	13 kDa, 6.065
Gene length, protein length	357 bp, 119 aa
Immediate neighbours	yaaT, yabB
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/>

The gene

Basic information

• Locus tag: BSU00330

Phenotypes of a mutant

strongly reduced growth rate in minimal medium PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: negative control of replication initiation PubMed

• Protein family: yabA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: leucine zipper

• Modification:

• Cofactor(s): Zn cluster

• Effectors of protein activity:

• Interactions: DnaA-YabA-DnaN PubMed

• Localization:

Database entries

• Structure:

• UniProt: P37542

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Philippe Noirot, Jouy-en-Josas, France Homepage<br> Alan Grossman, Cambridge, MA, USA Homepage

References

Reviews

<pubmed> 20157337 </pubmed>

Original publications

<pubmed> 19578359,,12060778 16461910, 19737352 19081080 </pubmed>