Difference between revisions of "XylR"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of xylan and xylose utilization | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of xylan and xylose utilization | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17590 xylR] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]''' | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[xynB]]'', ''[[xylA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[xynB]]'', ''[[xylA]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU17590 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU17590 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU17590 Advanced_DNA] |
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Revision as of 12:55, 13 May 2013
| Gene name | xylR |
| Synonyms | |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of xylan and xylose utilization |
| Gene expression levels in SubtiExpress: xylR | |
| Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
| MW, pI | 38 kDa, 5.819 |
| Gene length, protein length | 1050 bp, 350 aa |
| Immediate neighbours | xynB, xylA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
utilization of specific carbon sources, transcription factors and their control
This gene is a member of the following regulons
The XylR regulon
The gene
Basic information
- Locus tag: BSU17590
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription repression of the xylA-xylB and the xynP-xynB operons
- Protein family: ROK (nagC/xylR) family (according to Swiss-Prot)
- Paralogous protein(s): GlcK
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: inducer: xylose
Database entries
- Structure:
- UniProt: P94490
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: xylR (according to DBTBS)
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP270 (erm), GP1302 (aphA3), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Your additional remarks
References
M K Dahl, D Schmiedel, W Hillen
Glucose and glucose-6-phosphate interaction with Xyl repressor proteins from Bacillus spp. may contribute to regulation of xylose utilization.
J Bacteriol: 1995, 177(19);5467-72
[PubMed:7559331]
[WorldCat.org]
[DOI]
(P p)
M K Dahl, J Degenkolb, W Hillen
Transcription of the xyl operon is controlled in Bacillus subtilis by tandem overlapping operators spaced by four base-pairs.
J Mol Biol: 1994, 243(3);413-24
[PubMed:7966270]
[WorldCat.org]
[DOI]
(P p)
F Titgemeyer, J Reizer, A Reizer, M H Saier
Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria.
Microbiology (Reading): 1994, 140 ( Pt 9);2349-54
[PubMed:7952186]
[WorldCat.org]
[DOI]
(P p)
C Kauder, R Allmansberger, D Gärtner, D Schmiedel, W Hillen
An operator binding-negative mutation of Xyl repressor from Bacillus subtilis is trans dominant in Bacillus megaterium.
FEMS Microbiol Lett: 1993, 109(1);81-4
[PubMed:8319885]
[WorldCat.org]
[DOI]
(P p)
D Gärtner, J Degenkolb, J A Ripperger, R Allmansberger, W Hillen
Regulation of the Bacillus subtilis W23 xylose utilization operon: interaction of the Xyl repressor with the xyl operator and the inducer xylose.
Mol Gen Genet: 1992, 232(3);415-22
[PubMed:1588910]
[WorldCat.org]
[DOI]
(P p)
P Kreuzer, D Gärtner, R Allmansberger, W Hillen
Identification and sequence analysis of the Bacillus subtilis W23 xylR gene and xyl operator.
J Bacteriol: 1989, 171(7);3840-5
[PubMed:2544559]
[WorldCat.org]
[DOI]
(P p)
